I thought about this question for several months and talked to a bunch of knowlegable Porsche/tire guys. One of them works almost exclusively doing tires and suspension work for PCA Club Racing cars. After all of this I put a set of RE 750s on my 16" OEM rims and stuck with the OEM 205/225 setup. Most of the concerns I heard, and ultimately listened to, concerned going outside of the original Porsche specs for the 16" rims and possibly weakening the bead and sidewall due to the slight bulge over the rim from the larger tires. What I was told again and again were two things:
1. Going to 225/245 was only a cosmetic gain and could compromise handling.
2. If you want bigger tires to fill out the wheel wells - my original goal - get 17" rims. Upsizing tires is not a wise course of action.
I probably spent far too much time researching this. One problem I kept running in to was that 245/16s are not easy to find and really cut down on my tire choices.
So far I love the RE 750s but after a whole 40 miles I will reserve judgement. I wish Tire Rack would delete all reviews under 5000 miles!